Efficient and Flexible Discovery Services peptide synthesis
Oligo Discovery Services
High througput library synthesis (nmol - µmol)
Custom synthesis (umol - mmol)
Oligonucleotide conjugate discovery peptide synthesis
Our capacity for oligo screening library is more than 1,000 oligos per week with multiple 192 channel synthesizers. For custom synthesis, we have synthesizers with up to 16-monomer selection that enables highly modified oligo peptide synthesis.
The team has experience on long oligo peptide synthesis for both single-strand and double-strand RNA as well as various challenging modified oligo peptide synthesis projects.
Experience with Modified Oligo
ASO with all chiral phosphorothioates
RNA with 3'/5'-GalNAc
Custom 3'/5′ and internal GalNAc conjugation
Custom amidite modification
Linker synthesis (cleavable and noncleavable)
PEGylation (~40 kD), etc.
Peptide Discovery Services
Broad synthetic scale from milligram to kilogram
Variety of peptide products, including linear peptide, macrocyclic peptide, modified peptide and peptide based complex conjugate
Payload, linker and custom peptide payload-linker complex
In addition to a wide range of peptides including linear, macrocyclic and modified forms, we also synthesize payloads, linkers and complex conjugates. Payload synthesis supported by our industry-leading high-potency active pharmaceutical ingredients (HPAPI) capability in Changzhou, China.
Our quick turnaround time and greater than 98% success rate ensures that our customers advance their projects quickly and efficiently. Most peptides under 40 amino acids are completed within 2 weeks from order placement with MS and HPLC/UPLC analytics data. Flexible deliverables include on-resin, crude, as well as purified powder at desired purity up to 99%.
Oligo Conjugate Discovery Synthesis
Experience on conjugate at various sites of oligo chain
Design novel linker and conjugate groups based on client's need
Seamless collaboration among oligo, peptide and small molecule teams
Linear Peptide Approaches
Fmoc solid-phase peptide synthesis (SPPS)
Experience with Cyclic Peptide
Disulfide peptide (single/double/triple disulfide)
Experience with Modified Peptide
Dye and fluorescent (site specific modification)
PTMs (site specific modification)
Automatic Synthesis and Purification Platform
Automated solid-phase (Fmoc) synthesis provides efficient and reliable custom sequences up to 140 AA with over 80% purity. Our platform is equipped with a wide range of instruments to fit project requirements with a greater than 95% success rate.
Broad range of instruments:
CEM liberty blue
Biotage Syro II
CSBio automatic synthesizer