Startup Guides > Psychedelics are psychoactive substances that alter cognition and perception. These chemicals include psilocybin (found in magic mushrooms), lysergic acid diethylamide (LSD), mescaline, dimethyltryptamine (DMT), and 4-phosphoryloxy-N, N-dimethyltryptamine. This class of drugs has shown to be therapeutic in patients with severe depression.